Figure 4.
Effect of anti-CD33 antibody on engraftment of AML and cord blood cells. Anti-CD33 antibody (or isotype control) was incubated with either AML or cord blood cells prior to injection into NOD/SCID (AML samples no. 1 and no. 13 and cord blood MNCs) or NOD/SCID-β2m-/- (sample no. 4 and cord blood Lin-CD34+CD38- cells) mice. Each symbol represents one mouse. Open symbols represent mice given injections of cells incubated with isotype control. Filled symbols represent mice given cells incubated with anti-CD33 antibody. Triangles represent mice given injections with AML and diamonds represent mice given injections with cord blood. Horizontal bars represent mean percentage engraftment.