Figure 5.
The transcription signature of AID+ and CD30+ B cells. AID is red-brown; the other marker is purplish in each image. Original magnification ×40.(A) A subset of AID+ cells display dotlike CCL22 positivity. (B) AID and JunB are largely nonoverlapping. (C-E) AID+ cells (red brown) inside and outside the GC (star) are E47+, Id2–, and largely cMYC–. (E-G) By comparison, CD30+ cells (red brown) show a reversed staining pattern, being E47– but Id2+ and cMYC+. Scale bar: 1 μm at ×40, 4 μmat ×10, and 10 μmat ×4.