Distribution of the 257 patients with NRAS mutations within cytogenetic subgroups. Significant differences compared with the cohort of 2245 patients with NRAS^wt and available cytogenetics are labeled with asterisks. Normal karyotype, 109 of 1198 (9.1%); t(15;17), 2 of 102 (2%) (*P = .005); t(8;21), 13 of 132 (9.8%); inv(16), 50 of 133 (37.6%) (**P < .001); 11q23/MLL, 3 of 77 (3.9%) (***P = .062); inv(3)t(3;3), 11 of 41 (26.8%) (****P = .001); complex typical karyotype³⁷ , 4 of 258 (1.6%) (*****P = .001); complex atypical karyotype³⁷ , 7 of 56 (12.5%); +8, 18 of 122 (14.8%); 5q–/–5, 4 of 24 (16.7%); 7q–/–7, 4 of 58 (6.9%); other aberrations, 32 of 301 (10.6%); total, 257 of 2502 (10.3%).