Plaque formation in entire aortic trees. Sudan IV staining of aortic trees of male (A) L^–/–/A^–/– and (B) L^–/–/A^–/–/FG^–/– mice at 24, 36, and 48 weeks of age, showing the extent of lipid-containing plaque (red/orange stains) in these strains. (C) The percent of total surface occupied by plaque in the aorta between L^–/–/A^–/– (▪) and L^–/–/A^–/–/FG^–/– (▦) mice. N = number of mice. *P < .001 between pairs.