Plaque formation in aortic sinuses of mice. H&E stains of aortic sinuses from L^–/–/A^–/– (A,C,E) and L^–/–/A^–/–/FG^–/– (B,D,F) mice at 24, 36, and 48 weeks of age. Red arrows indicate the leaflets of aortic valves; yellow arrows, the vascular wall of aorta; and black arrows, the plaques. Original magnification, × 40. (G) Plaque sizes in aortic sinuses of L^–/–/A^–/– (▪) and L^–/–/A^–/–/FG^–/– (▦) mice, as revealed by morphometric analysis of H&E-stained slides. *P < .05.