Figure 4.
Figure 4. Activation of HTLV-1 Tax leads to induction of c-FLIP and Bcl-xL. Jurkat ERtax and ERΔtax cells were stimulated with 30 μg/mL anti-CD3, 2 μM HT, or both for 24 hours. (A) Lysates were subjected to Western blot analysis with antibodies against c-FLIP and Bcl-xL. Expression of tubulin was analyzed as loading control. (B) No modulation of the DISC components FADD and pro–caspase-8 and of Bcl-2. ERtax cells were stimulated with 30 μg/mL anti-CD3, 2 μM HT, or both for 24 hours. Lysates were subjected to Western blot analysis with antibodies against FADD, pro–caspase-8, and Bcl-2. Expression of tubulin was analyzed as loading control. Induction of c-FLIP and Bcl-xL was used as positive control for stimulation.

Activation of HTLV-1 Tax leads to induction of c-FLIP and Bcl-xL. Jurkat ERtax and ERΔtax cells were stimulated with 30 μg/mL anti-CD3, 2 μM HT, or both for 24 hours. (A) Lysates were subjected to Western blot analysis with antibodies against c-FLIP and Bcl-xL. Expression of tubulin was analyzed as loading control. (B) No modulation of the DISC components FADD and pro–caspase-8 and of Bcl-2. ERtax cells were stimulated with 30 μg/mL anti-CD3, 2 μM HT, or both for 24 hours. Lysates were subjected to Western blot analysis with antibodies against FADD, pro–caspase-8, and Bcl-2. Expression of tubulin was analyzed as loading control. Induction of c-FLIP and Bcl-xL was used as positive control for stimulation.

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