Figure 4.
In vivo expression of BDD porcine fVIII from genetically modified hematopoietic cells. Plasma fVIII activity levels (symbols) were determined following transplantation of BDD porcine fVIII transgene–modified hematopoietic progenitor cells into hemophilia A mice. Recipient mice were preconditioned with a lethal dose of TBI (11 Gy) and received a transplant of 3 × 105 transduced Sca-1+ cells (A), 3 × 105 transduced c-kit+ cells (B), or 2 × 106 whole bone marrow cells (C) derived from one of the animals that underwent transplantation in panel A. Each line represents an individual mouse.
