LYL8 depletion does not alter antitumor activity. Lethally irradiated BALB.B mice underwent transplantation on day -1 with 1 × 10⁵ F9 cells and on day 0 with 5 × 10⁶ B6 TCD-BM cells and 1 × 10⁶ CD3⁺ B6 T cells. Survival was followed for 60 days and is plotted as Kaplan-Meier curves (representative of 2 combined experiments for each condition). ○ indicates no T cells (n = 8); □, nondepleted (n = 4); ♦, LYL8-depleted (n = 11); ▪, HSV8 control-depleted (n = 10). Depletion was 95.4% efficient in these transplants. ♦ versus ○, P < .001; ▪ versus ○, P < .001; □ versus ○, P = .003; ♦ versus ▪, P = not significant (ns); ♦ versus □, P = ns; ▪ versus □, P = ns.