Amino acid alignment of the α_MI-domain sequence Lys²⁴⁵-Arg²⁶¹ with other integrin α subunit I-domains. The α_MI-domain sequence was aligned with human α_X, α_D, α_L, α₁, α₂, α₁₀, α₁₁, and α_E using the National Center for Biotechnology Informatics (NCBI) database. Numbers on the right indicate the homology between α_M (assigned a value of 100%) and other α subunits expressed as the percentage of identical residues (shown in bold). Dots above the α_DI-domain sequence indicate residues homologous between α_D and α_M. Residues identified as critical for ligand binding in the α_MI-domain^13,14  are underlined.