FGF-2–induced p38 phosphorylation in the presence of PDGF-BB. (A) FGF-2–induced p38 phosphorylation was significantly reduced by PDGF-BB (10 ng/mL each) (^*P < .001 vs FGF-2). (B) PDGF-BB lost the inhibitory effect of FGF-2 mitogenic activity on selective p38 activation with Anisomycin (^*P < .05). (C) Anisomycin pretreatment abolished PDGF-BB reduction of FGF-2–mediated p38 phosphorylation (^*P < .001 vs FGF-2). Bars indicate quantification of 3 experiments; representative Western blots are shown below the bar graphs in panels A and C.