Cytogenetics of patients with D816 mutations. (A) Cytogenetic analyses were available in 1913 patients. The figure shows the frequency of D816 mutations within different cytogenetic subgroups. The overall frequency of this mutation was 1.7%. ^*Higher percentage of D816 mutations compared with the whole cohort as assessed by Fisher exact test (P < .05). The trisomy 4 was present as sole cytogenetic aberration as well as concomitantly with other aberrations. (B) The percentage of mutations in KIT and FLT3 in the indicated subgroups is shown. The overlap of RTK mutations is not shown in the figure. Thus, patients showing 2 different mutations are rated twice.