Adoptive transfer of T and B cells into mouse models of BLS. (A) Proliferation of CFSE-labeled Vα3⁺ T cells from 2D2 TCR transgenic mice after adoptive transfer into RFX5^-/-, CIITA^-/-, Aα^-/-, and C57BL/6 mice and immunization with MOG p35-55. The histogram analysis of CFSE fluorescence of CD4⁺Vα3⁺PI^- lymphocytes is shown. (B) Survival of CD45.1⁺ B cells after transfer into Aα^-/- or RFX5^-/- hosts. The dot plots show B220 and CD45.1 expression of non-B-cell marker-negative splenocytes 3 weeks after transfer. The histogram analysis depicts the I-A^b expression of the indicated populations. The number in each quadrant represents the percentage of cells in that quadrant.