Figure 2.
Figure 2. NO induces DC migration toward CCL19/MIP-3β. (A) Surface CCR7 expression of iDCs matured or not for 24 hours with LPS (0.3 μg/mL) in the presence or absence of 100 μM NOR4 or DMSO. The mean fluorescence intensity (M) and percentages of positive cells (%) are indicated. Data shown are representative of more than 10 independent experiments. (B) iDCs matured or not for 24 hours with 0.3 μg/mL LPS in the presence or absence of 100 μM NOR4 or DMSO were tested for their migration toward CCL19. Data shown are mean of duplicate cultures ± SEM and are representative of 9 independent experiments. (C) iDCs were matured for 24 hours with graded doses of LPS with medium only (•), 100 μM NOR4 (♦), or 0.001% DMSO (▴) and tested for migration toward CCL19. Data are from 1 representative experiment of 2 performed using cells from different donors.

NO induces DC migration toward CCL19/MIP-3β. (A) Surface CCR7 expression of iDCs matured or not for 24 hours with LPS (0.3 μg/mL) in the presence or absence of 100 μM NOR4 or DMSO. The mean fluorescence intensity (M) and percentages of positive cells (%) are indicated. Data shown are representative of more than 10 independent experiments. (B) iDCs matured or not for 24 hours with 0.3 μg/mL LPS in the presence or absence of 100 μM NOR4 or DMSO were tested for their migration toward CCL19. Data shown are mean of duplicate cultures ± SEM and are representative of 9 independent experiments. (C) iDCs were matured for 24 hours with graded doses of LPS with medium only (•), 100 μM NOR4 (♦), or 0.001% DMSO (▴) and tested for migration toward CCL19. Data are from 1 representative experiment of 2 performed using cells from different donors.

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