Figure 4.
![Figure 4. Ability of antibodies to the IL-7R and/or c-Met to inhibit the stimulation of mouse bone marrow cells by rIL-7 or scIL-7/HGFβ. Culture-generated BM cells (4 × 105 cells/well) from IL-7-/- mice were incubated for 3 days in the presence of rIL-7 (10 μg/mL) or scIL-7/HGFβ (30 μg/mL) to which antibodies against IL-7Rα, γc, and/or c-Met (10 μg/mL) were added. Incorporation of [methyl-3H] thymidine (mean counts per minute [CPM] ± SD) was determined after a 12-hour pulse. *P < .05 between antibody-treated and untreated values (similar results were obtained with isotype controls). **P < .05 versus value for anti-IL-7Rα or anti-HGFR alone. One representative experiment of 4 is shown.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/107/5/10.1182_blood-2005-08-3470/2/zh80050692160004.jpeg?Expires=1735534812&Signature=rlVBqOI0IHLK-2BMxNY1GMRRMqb5OHi5pxhGFwyfGQ6mMVNgi~qPmeXmOjUDrsu6zqj94EfbQ-OUAX9wCZHFJac6O2c0-cH2wcfsqNmVUnZqmfUN1U2MjWEPv9dlYPnu2LNbsca4fW5~Ii~VAKGiIYIPRAc39TXTsMpUOaLviwd-PNxHRLV8P~tGPU3EaK0aGFLlHyxl6acfuCSIBA0YqIiT1SyiBmtvUPfN~Uddcz8leUaCr3HJtOgRblfCL-~zWLxW7HRawh6MbTZFe5-w54tZ~YWFVadUxcRXHaB7I77f1dYCOqZMCeKsOuHrhXb~srDy4ArnwdEyTjTyzPKCdA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Ability of antibodies to the IL-7R and/or c-Met to inhibit the stimulation of mouse bone marrow cells by rIL-7 or scIL-7/HGFβ. Culture-generated BM cells (4 × 105 cells/well) from IL-7-/- mice were incubated for 3 days in the presence of rIL-7 (10 μg/mL) or scIL-7/HGFβ (30 μg/mL) to which antibodies against IL-7Rα, γc, and/or c-Met (10 μg/mL) were added. Incorporation of [methyl-3H] thymidine (mean counts per minute [CPM] ± SD) was determined after a 12-hour pulse. *P < .05 between antibody-treated and untreated values (similar results were obtained with isotype controls). **P < .05 versus value for anti-IL-7Rα or anti-HGFR alone. One representative experiment of 4 is shown.
