Model of p14 NF-E4 repression of γ-globin gene expression. (A) At the actively transcribing γ-globin gene promoter p45 NF-E2 is recruited through its interaction with TAF_II130. This interaction is stabilized by the assembly of the SSP complex on the SSE adjacent to the TATA box and, in particular, the CP2/TAF_II130 interaction. Subsequent to this, RNA polII is recruited to the promoter to mediate transcription. (B) In the context of increased levels of p14 NF-E4, CP2 and TAF_II130 are sequestered away from the SSE and the recruitment of p45 NF-E2 is lost. As a result, recruitment of RNA polII is also lost and γ-globin gene transcription is repressed.