Figure 7.
Expression of N-cadherin and SDF-1 by HMRCs that interact with human hematopoietic cells. (A) CD34+ cells (arrowheads) appear to colonize near the bone-lining HMRCs. (B-C) Bone-lining HMRCs colocalize with CD34+ cells (arrowheads) through the asymmetrical expression of N-cadherin. (D-E) Higher magnifications of panels B and C. (F-H) An HMRC in the endosteal hematopoietic parenchyma (arrow) expresses SDF-1 and interacts with a few eYFP hematopoietic cells. All bars represent 10 μm.