Gene expression based centrosome index (CI) in PC neoplasm. (A) CI increased progressively from MGUS (n = 23; median CI, 2.27; range, 1.56-3.90) to SMM (n = 25; median CI, 2.91; range, 1.58-3.91) to MM (n = 97; median CI, 3.36; range, 1.29-6.97). The pairs represented by the brackets were significantly different. (B) In the 20 patients with MM in group 2 in which IF was also performed, the CI was highly correlated with the percentage of clonal plasma with abnormal (> 4) centrin signals (Spearman correlation coefficient r = 0.97; P < .001).