Deferasirox produces a reduction in the absolute liver iron concentration. Results are shown according to the actual initial dose administered. Doses of 5 and 10 mg/kg were too low to maintain or reduce absolute LIC, whereas a dose of 20 mg/kg maintained LIC and 30 mg/kg reduced LIC. A similar dose response was not observed in the groups of patients receiving deferoxamine at doses lower than 50 mg/kg, likely because the mean doses of deferoxamine actually administered were within a more narrow range (33.9-42.2 mg/kg versus 5-20 mg/kg). ▪ indicates deferasirox; □, deferoxamine. Mean ± SD.