The effect of deferasirox on serum ferritin in different dose groups was distinguishable at 3 months. Monthly changes in serum ferritin according to dose are shown, and changes from baseline are plotted at intervals of 4 weeks. Serum ferritin levels were available through EOS for 96% of patients on both deferasirox and deferoxamine arms. Panel A shows deferasirox; panel B, deferoxamine. After 12 weeks, differences between deferasirox dose groups (5 and 10 mg/kg vs 20 mg/kg vs 30 mg/kg) were already apparent. As the actual doses of deferoxamine administered were relatively similar for patients with LIC values lower than 14 mg Fe/g dw, the finding of similar changes in serum ferritin, as observed, would be expected. EOS indicates end of study. Values represent mean ± 2 SEM.