Localization of point mutations in the JM domain of FLT3 (FLT3-JM-PMs) found in patients with AML. The top panel shows the FLT3-WT juxtamembrane protein sequence from aa 573 to 600. Below are the four point mutants found in our study (^*) and the study of Stirewalt et al¹⁶  (†) in patients with AML.