Protective effect of DC_regs against lethality induced by murine experimental endotoxemia and bacterial peritonitis. (A, B) D-GalN-sensitized mice (5 animals/group) were given intraperitoneal injections of LPS (1 μg/mouse) 2 hours after the intraperitoneal injection of various doses (10⁵-10⁶/mouse) of mDCs (A) or DC_regs (B). ^*P < .01 compared with the untreated mice by the log-rank test (A, B). †P < .01 compared with mice given injections of 10⁵ DC_regs per mouse; ‡, compared with or 5 × 10⁵ DC_regs per mouse by the log-rank test (B). (C) Mice (5 animals/group) were given intraperitoneal injections of mDCs or DC_regs (10⁶/mouse) 2 hours after intraperitoneal injection of LPS (1 mg/mouse). ^*P < .01 compared with the untreated mice; †, compared with mice given injections of mDCs, by the log-rank test. (D) Mice (5 animals/group) were given intraperitoneal injections of mDCs or DC_regs (10⁶/mouse) 2 hours after intraperitoneal injection of heat-killed E coli (5 × 10⁸/mouse). ^*P < .01 compared with the untreated mice; †, compared with mice given injections of mDCs, by the log-rank test. Survival was monitored at the indicated times, and the results are representative of 4 experiments with similar results.