Similar magnitude or breadth of SIV-specific T-cell responses in naturally SIV-infected SMs grouped by infecting SIVsmm viral subtypes. A total of 84 animals were included in this study. (A-B) Magnitude of CD3⁺CD8⁺ (A) and CD3⁺CD8^- (B) T-cell responses in SIV-infected SMs grouped by infecting viral subtype. One-way nonparametric ANOVA (Kruskal-Wallis) of all groups followed by Dunn multiple comparison test found no significant differences between the groups. Horizontal lines indicate mean values. (C) Percentage of CD3⁺CD8⁺ T cells producing IFN-γ in response to pools of SIVsmm-Gag subtype-1 or -2 “consensus” peptides in 9 SIVsmm subtype-1-infected and 10 SIVsmm subtype-2-infected SMs. Each bar represents an individual animal. No significant differences were observed between groups using a 2-way ANOVA. Error bars indicate standard deviation.