Figure 7.
Lack of correlation between magnitude of SIV-specific T-cell responses and the level of T-cell proliferation measured as fraction of Ki67+ T cells. (A-B) Comparison of the percent of Ki67+ cells in the CD3+CD8+ (A) or CD3+CD4+ (B) T-cell subsets in SIV-infected and uninfected animals (**P < .01, ***P < .001 as determined by the Mann-Whitney U test.) (C-D) Lack of correlation between the percent of CD3+CD8+ (C) and CD3+CD4+ (D) T cells expressing the Ki67 proliferation marker and the magnitude of SIV-specific responses mediated by CD3+CD8+ (C) and CD3+CD8- (D) T cells. P = ns indicates that the P value of the correlation coefficient is more than .05 (Spearman rank). Error bars in panels A and B indicate standard deviation.