Systemic hF.IX levels in for C3H/HeJ hemophilia B mice treated with hF.IX-derived peptide 2A-54 (▴) or saline control (•) after hepatic AAV-hF.IX gene transfer. (A) Two weeks. (B) Twenty weeks. Each data point represents an individual animal. Horizontal bars show average hF.IX levels in plasma. Numbers of mice are indicated for each cohort and time point.