IL-7Rα and IL-15Rα expression on total lymphocyte populations. (A) Representative staining profiles for IL-7Rα expression (left) and IL-15Rα expression (right) on PBMCs costained with anti-CD8 mAb. Analysis was restricted to the lymphocyte population (ie, excluding monocytes) by gating on cell size. These results involve the same IM donor, studied in acute phase, 3 months later, and 2 years later, and the same healthy EBV carrier as in Figures 1 and 2. Percentage values refer to the percentage of IL-R-positive cells among the CD8⁺ population. (B-C) Scatterplots summarizing IL-7Rα expression (left panel) and IL-15Rα expression (right panel) on total CD8⁺ T cells during and at intervals after EBV-associated IM (B) or CMV-associated IM (C). In all plots, results are expressed as the percentage of CD8⁺ cells that are IL-7Rα or IL-15Rα positive. Each symbol shows the value for a particular donor within a particular time interval after infection. Cumulative results from IL-R stainings carried out on the CD8⁺ T cells of 22 healthy EBV carriers with no history of EBV-IM (light gray shading) and 30 healthy EBV-naive individuals (dark gray shading) are shown in the top panels; similarly, results from 10 healthy CMV carriers and 5 healthy CMV-naive individuals are shown in the bottom panels. Horizontal lines represent the median value in each case. Statistical analysis was performed using the Mann-Whitney test; significant differences are indicated by asterisks (^*P < .001).