Primary CML cells contain elevated levels of ROS and oxidative DNA lesions. (A) ROS levels in mononuclear bone marrow cells from healthy volunteers (N), CML-CP, and CML-BC patients were analyzed by fluorescence; bars show mean ± SD; ^*P = .02, ^**P = .001 compared with N group. (B) 8-oxoG nuclear staining detected by immunofluorescence. The nuclei borders are marked in blue.