T-cell depletion does not reverse the NK-cell developmental defect in tumor-bearing mice. CD4 and CD8 T cells were depleted by the administration of GK1.5 and 2.4.3 on day -3, 0, and +3 of tumor-cell challenge. Control PBS-treated, EL4-challenged, and T-cell-depleted (TCD) EL4-challenged mice were evaluated for NK-cell differentiation. (A) Effects of GK1.5 and 2.4.3 on T-cell depletion in bone marrow. (B) CD11b expression on NK1.1⁺CD3^- bone marrow cells. Data are representative of 2 separate experiments.