Enhanced embolus formation in α2A–/– mice. Thrombosis was induced in mesenteric arteries by topical application of FeCl3. (A) In wild-type mice 95% of formed thrombi were able to occlude, whereas in α2A–/– mice only 55.5% of formed thrombi were able to occlude. Each symbol represents one monitored arteriole, and horizontal lines indicate quartiles of occlusion time. (B) Quantitative analysis of embolus formation in control (1.7 ± 0.32) and mutant (3.1 ± 0.39) mice are presented as the amount of thrombi that detached during the observation period from the viewing field. Results are presented as mean ± SEM. (**P = .01–.05) (C) Representative pictures of 1 experiment are shown for better illustration. Indicated time points represent minutes after FeCl3-induced injury. Images were captured as described in the caption for Figure 1C, except that a 10 ×/0.25 Ph1 objective was used.
