Figure 1.
IL-2 and IL-15 are equivalent mitogens for antigen-primed CD8+ T cells. (A) Data show tritiated [3H]-thymidine incorporation into P14 LCMV CD8+ T cells primed with LCMV gp33-41 peptide for 2 days and thereafter cultured in the indicated concentration of IL-2 (CD8IL-2) or IL-15 (CD8IL-15) or in medium alone for 24 hours. (B) Cell numbers of antigen-activated CD8+ T cells maintained in exponential proliferation with 20 ng/mL IL-2 (CD8IL-2), 20 ng/mL IL-15 (CD8IL-15), and medium over the indicated period of days. Graphs represent the results of 7 or more experiments. Error bars indicate SD.