Effect of mAb to α4, β1, β7, or α4B7 integrins on MCp recruitment to the inflamed lung in C57BL/6 mice. (A) Number of lung MNCs per mouse recovered from OVA-sensitized BALB/c mice not challenged (No Chall) or from mice that had received injections of HBSS or the indicated mAb and then challenged with aerosolized OVA. Values are the mean ± SEM from 6 separate experiments with following determinations in each group: HBSS (9); anti-α4 (3); anti-β1 (5); anti-β7 (3); anti-α4β7 (3). (B) Concentration of MCp's (MCp's/10⁶ MNCs) in the lungs of the same mice. (C) Total number of MCp's per mouse in the lungs of the same mice. ^*Indicates statistical significance (P < .05) as determined by the 2-tailed Student t test.