Proposed schematic signaling pathway from the activation of cPLA₂ to the FcγRIIA protein surface expression, during differentiation in PLB cells. The scheme is based on the present study demonstrating that during differentiation of PLB cells PGE₂ is synthesized from AA released by cPLA₂. PGE₂ is released from the cells and through the EP4 receptor exerts its effect on PKA activation, CREB phosphorylation, and CREB-CRE binding activates FcγRIIA gene and protein expression.