Differential gene expression as a result of BCR-ABL kinase activity. DNA microarray analysis was performed on FDCP-Mix control cells and cells expressing BCR-ABL kinase activity. The microarray identified genes differentially expressed as a result of the BCR-ABL kinase activity, a small subset including CDK4, MIP 1α, CCN3 is shown (A). Northern blotting was used to confirm expression of these genes in control cells (-) and BCR-ABL kinase-active cells (+) after 24 hours in culture. Fold changes in gene expression are shown (B).