Postrelapse survival of MM patients enrolled in Total Therapy 2 according to Amp1q21 and the copy number of 1q21 at relapse. Kaplan-Meier analysis of postrelapse survival is shown in relation to no Amp1q21 (up to 2 copies of 1q21, n = 12) or Amp1q21 (3 or more copies of 1q21, n = 33) at relapse (top) and up to 2 copies (n = 12), 3 copies (n = 13), or 4 or more copies (n = 20) of 1q21 at relapse (bottom) determined by interphase FISH. At the time of analysis, the median follow-up of a postrelapse survival was 17 months (range, 0.3 to 78) in this analysis.