Identification of changes in phosphorylation and total protein levels that preferentially occur in GSI-sensitive cell lines. (A) Significant list of phospho-epitopes and proteins identified by significance analysis of microarrays (SAM) along with their direction of change and (d)-score rank. See “Materials and methods” for details. When 2 ranks are shown for a particular epitope, 2 distinct antibodies with the same specificity were used. (B) Presentation of fold change measurements as scatter plots for SAM-identified analytes listed in (A). Each dot represents an individual cell line. S denotes sensitive cell lines. R denotes resistant lines. All fold-change data points are logged in base 2 and median-centered for their corresponding cell line. Horizontal line indicates the mean fold change of the group. For cdc2 and p-S6 RP, 2 distinct antibodies were used.