Pathological analysis of diseased mice. (A) The average WBC counts and spleen weight of transplant recipients at death. The error bars represent the standard deviation. (B) Histologic analysis of spleens and livers of representative control and experimental mice that received a transplant of Mig-p210–transduced Ubp43^+/+ and Ubp43^−/− bone marrow cells. The tissue sections were stained by hematoxylin and eosin. Images from a Leica DMLB microscope with 10×/0.25 or 20×/0.40 objectives were captured with a Spot 2 digital camera (Diagnostic Instruments, Sterling Heights, MI) running Spot V4.64 software, and were processed with Adobe Photoshop v.5.5 (Adobe Systems, San Jose, CA).