IFNα/β signaling plays a critical role in resistance to leukemia development in Ubp43-deficient cells. (A) Kaplan-Meier survival curve of mice that received a transplant of MigR1- or Mig-p210–transduced wild-type bone marrow cells (WT) or Ubp43 and IFNα/β receptor subunit R1 (Ifnar1) double-deficient bone marrow cells (DK). The result is summarized from 2 separate sets of transplantation experiments. (B) WBC counts and spleen weight of moribund mice.