Sensitivity of Bcr-Abl kinase domain mutants to Abl kinase inhibitors. Imatinib: sensitive (≤1000 nM), intermediate (≤3000 nM), insensitive (>3000 nM). Nilotinib: sensitive (≤50 nM), intermediate (≤500 nM), insensitive (>500 nM). Dasatinib: sensitive (≤3 nM), intermediate (≤60 nM), insensitive (>60 nM). ^aThe IC₅₀ value is the concentration of inhibitor resulting in a 50% reduction in cell viability.^8,12,21,29  †IC₅₀ values are from Burgess et al, 2005.²¹  ‡IC₅₀ value is from Shah et al, 2002.²⁹  §IC₅₀ value was estimated from Shah et al, 2004.⁸