The PfEMP-1 molecule, protein domains, and gene structure.¹¹²  The cartoon at the top indicates that PfEMP-1 contains both a CD36-binding domain and a lectin-like binding domain. This depiction is used in Figures 3 and 4. A schematic of the expressed PfEMP-1 protein is shown in the center. DBL-1α, far left in stripe binds to blood group A or B determinants. The CD36-binding region (cysteine-rich interdomain region-1) is shown in black. Two different examples of var genes encoding PfEMP-1 are shown at the bottom. For each parasite, a single PfEMP-1 protein, selected from among 50 to 60 different var genes, is expressed on the RBC surface.¹¹²  HS, heparan sulfate; CR1, complement receptor 1; ICAM-1, intracellular adhesion molecule 1; CSA, chondroitin sulfate A; ATS, acid terminal segment.