Proposed model for cytoadhesion of parasitized RBCs to CD36. Infected RBCs expressing PfEMP-1 can bind to CD36 (platelet glycoprotein IV) determinants on other cells. On the left, an infected cell binds to endothelial CD36 (direct sequestration). In the center, an infected cell binds to CD36 expressed on activated platelets, which in turn bind to endothelial cells via VWF. The lower levels of VWF in group O patients may confer a survival advantage. Inflammation, endothelial activation, NO depletion, reduced ADAMTS13 activity, and procoagulant microparticles may contribute to cytoadhesion. TNF-α, tumor necrosis factor α; ADAMTS13, a disintegrin-like and metalloprotease with thrombospondin type 1 motifs. Copyright Kimberly Main Knoper; used with permission.