Cytokine production in the LTB4-containing EBV-infected cultures. IFN-γ, IL-15, IL-12, and IL-18 in the supernatants of 3-day-old cultures were tested by ELISA. Dose response of the added LTB4 in total and in monocyte-depleted cultures. (A) IFN-γ. (B) IL-15. (C) IL-12. (D) IL-18. The results represent means plus or minus SD of 4 independent experiments. * indicates P < .05, and **P < .01 compared with untreated cultures.