Kaplan-Meier event-free survival (EFS) estimates of randomized children receiving intermediate-dose (1 g/m2, solid line, n = 141; censored = 50; pEFS = 0.36 ± 0.04) or high-dose (5 g/m2, dashed line, n = 128; censored = 49; pEFS = 0.38 ± 0.04) methotrexate (P = .919).