Kaplan-Meier overall survival (OS) estimates at 10 years of randomized children receiving intermediate-dose (1 g/m2, solid line, n = 141; censored = 63; pOS = 0.47 ± 0.04) or high-dose (5 g/m2, dashed line, n = 128; censored = 55; pOS = 0.43 ± 0.04) methotrexate (P = .633).