Prognostic correlations between NPMI and FLT3-TKD. Overall survival (A) and event-free survival (B) of FLT3-TKD wild-type (FLT3-wt) versus FLT3-TKD mutated cases (FL3T-TKDmut) in dependence on NPM1 mutations. Overall survival (C) and event-free survival (D) of FLT3-TKD wild-type (FLT3-wt) versus FLT3-TKD mutated cases (FL3T-TKDmut) in dependence on NPM1 mutations all cases that are FLT3-LM mutated. Overall survival (E) and event-free survival (F) of FLT3-TKD wild-type (FLT3-wt) versus FLT3-TKD mutated cases (FL3T-TKDmut) in dependence on NPM1 mutations, exclusive all cases that are FLT3-LM mutated in de novo normal karyotype AML.