Analysis in human Hodgkin lymphoma (HL) cell lines: L-428 and HD-MY-Z (nodular sclerosis) and L-1236 (mixed cellularity). (A) 25-miRNA signature. This figure shows the log₂ of fold change (−ΔΔCt) of the 13 miRNAs most differently expressed in the cell lines. The dotted line indicates a 4-fold difference in expression compared with the mean of expression of reactive lymph nodes. (B) Thirty-two of the 36 miRNAs differentially expressed in lymph nodes of nodular sclerosis and mixed cellularity subtypes were also differentially expressed in the cell lines. Panel B depicts only the 11 miRNAs with at least a 2-fold difference in expression between the 2 subtypes. Error bars represent SD.