Chromogenic in situ hybridization of cHL cases. Cytoplasmatic expression in Hodgkin and Reed-Sternberg cells of miR-21 (A), miR-134 (B), miR-138 (C), and miR-155 (D). miR-155 was used as positive control of the hybridization technique. (Microscope, Olympus BX51 [Olympus, Center Valley, PA]; camera, Olympus DP70; lens, UPIanFI 40×/0.75; software, Olympus DP Controller.)