Clinical outcome stratified according to FLT3/ITD and NPM1 mutant status in total cohort. (A) Impact on remission rate of an NPM1 mutation in FLT3/ITD⁺ and ITD⁻ patients. (B) Kaplan-Meier curves for relapse risk. (C) Impact on relapse rate of an NPM1 mutation in FLT3/ITD⁺ and ITD⁻ patients. (D) Kaplan-Meier curves for overall survival. O-E indicates observed minus expected; Var, variance; and NS, not significant.