American Society of Hematology

Figure 7

$Figure 7. p53 status affects KPT-185 sensitivity in primary AML cells. Primary AML samples were treated for 48 hours with 800 nM KPT-185 and 8 µM Nutlin-3a, and the annexin V–positive fractions were measured by flow cytometry. (A) AML samples with mutant p53 were less sensitive to KPT-185 compared with those with wild-type p53. (B) FLT3 mutations were associated with increased KPT-185 sensitivity in wild-type p53 samples. Results are expressed as mean ± standard error of the mean. (C) The extent of apoptosis induced by KPT-185 positively correlates with that induced by Nutlin-3a.$

p53 status affects KPT-185 sensitivity in primary AML cells. Primary AML samples were treated for 48 hours with 800 nM KPT-185 and 8 µM Nutlin-3a, and the annexin V–positive fractions were measured by flow cytometry. (A) AML samples with mutant p53 were less sensitive to KPT-185 compared with those with wild-type p53. (B) FLT3 mutations were associated with increased KPT-185 sensitivity in wild-type p53 samples. Results are expressed as mean ± standard error of the mean. (C) The extent of apoptosis induced by KPT-185 positively correlates with that induced by Nutlin-3a.

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