Loss of β-catenin prevents development of BM failure in Apc-deficient mice. (A) The number of white blood cells (WBC), neutrophils (NE), lymphocytes (LY), monocytes (MO), eosinophils (EO), basophils (BA), red blood cells (RBC), platelets (PLT), and hemoglobin (Hb) levels in PB from Apc^Δ/Δ, Apc^Δ/Δβ-catenin^Δ/Δ, β-catenin^Δ/Δ, or β-catenin^fl/fl chimeric mice (CM) 7-13 days after last pI-pC injection (n = 5). (B) Representative histological analysis of hematoxylin and eosin–stained sternum from Apc^Δ/Δ CM and Apc^Δ/Δβ-catenin^Δ/Δ CM 13 days after induction. (C) Numbers of total BM cells in Apc^Δ/Δ, Apc^Δ/Δβ-catenin^Δ/Δ, β-catenin^Δ/Δ, or β-catenin^fl/fl CM 7-15 days after induction (mean ± standard deviation, n = 5-10). *P < .05; **P < .01; ***P < .001.