Proposed model for Brg ATPase function in leukemia. BAF complexes expressed in quiescent long-term hematopoietic stem cells (LT-HSCs) (hscBAF) are assembled around the BRM ATPase, whereas leukemic BAF complexes (leukBAF) specifically contain the BRG ATPase. BRG is dispensable for long-term HSC maintenance, but is required for the full proliferative activity of both normal and leukemic HSCs.