Cluster DNA methylation signatures. (A) Heat map representation for the HELP fragments that are differentially methylated between NGCB cells and DLBCL cases in each cluster (moderated Student t test q value <0.05 and log fold change ≥1.5). Each row represents a single HELP fragment (probe set) and each column a single patient/normal sample. Yellow represents highly methylated (hypermethylated) fragments and blue represents fragments with lower methylation (hypomethylated). (B) Bar plot showing relative abundance of methylation gain and loss for each cluster signature. (C) Venn diagram depicting the overlap of differentially methylated HELP fragments among clusters B, D, and E.